Family: John SPENCER, 1st Earl Spencer / Margaret Georgiana POYNTZ (F37406)
m. 1755
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 | Hon. John SPENCER (1708-1746)
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 | Lady Georgina Caroline CARTERET (1716-1780)
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 | John SPENCER, 1st Earl Spencer (1734-1783)
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| Margaret Georgiana POYNTZ (1737-1814)
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| Lady Georgiana SPENCER, Duchess of Devonshire (1757-1806)  |
 | George John SPENCER, 2nd Earl Spencer (1758-1834) |
 | Lady Henrietta SPENCER, Countess of Bessborough (1761-1821) |
| Lady Charlotte SPENCER (1765-1766) |
| Lady Louisa SPENCER (1769-1769) |